Sildenafil Tablets (25mg, 50mg, 100mg)
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Sildenafil operates by preventing the breakdown of cyclic guanosine monophosphate (cGMP) by selectively targeting and inhibiting the cGMP-specific PDE5 enzyme. The subsequent increased presence of the cGMP nucleotide second messenger leads to the relaxation of the corpus cavernosum smooth muscle in the penis. This allows the arteries within to expand, ensuring a better blood supply to the organ, which consequently results in improved and longer-lasting erections.
Sildenafil from Canadian Pharmacy is a potent and fast-acting medication that is effective for 7 out of 10 men diagnosed with erectile dysfunction. However, it cannot produce the desired outcome unless the man consuming it is sexually stimulated. As a result, some form of erotic arousal is necessary for the man to achieve an erection.
How to Take
For most patients diagnosed with ED, the suggested dosage of Sildenafil citrate is 50mg taken 60 minutes before anticipated sexual activity. This dosage is typically sufficient to ensure a solid erection that lasts for approximately 4-6 hours. Depending on the drug’s effectiveness and the patient’s tolerance, the dosage may be reduced to 25mg or increased to 100mg. The suggested safe frequency of sildenafil administration is once daily on an as-needed basis. This means that men should only use the drug when they expect sexual activity within the next few hours.
To prevent any health issues and guarantee the best possible therapeutic result, any medication, including Generic Sildenafil, should be taken in strict compliance with the doctor’s advice. Do not consume more sildenafil citrate than what your doctor prescribes. It will not enhance the treatment’s effectiveness but may provoke a series of unwanted and dangerous side effects.
The medication works optimally when taken on an empty stomach, but it can also be consumed with light meals. Fatty foods may hinder the absorption of sildenafil and delay the onset of its action or reduce the medication’s effectiveness altogether. Alcohol is strictly not recommended with sildenafil, as they may interact dangerously and cause severe side effects such as a sudden drop in blood pressure, fainting, or seizures.
Possible Side Effects
Like any synthetic drug, sildenafil citrate may sometimes produce side effects in some patients. In most cases, the symptoms are mild and disappear quickly on their own. However, some of these may linger or be more serious in nature and thus require medical attention.
The most common mild side effects observed by patients who take sildenafil include:
- headache
- facial flushing
- blocked or runny nose
- lightheadedness
- indigestion
- sickness in the stomach
- vomiting
- backache
- muscular pain
- abnormal vision
- ringing in the ears
If these symptoms stay for a long time or get worse, contact your doctor for a consultation. Urgent medical assistance may be required if you start noticing any of the following manifestations:
- nose bleed that does not stop
- signs of an allergic reaction to the medication
- a prolonged and painful erection
- respiratory distress
- acute pain in the chest or arm
- fainting
- seizures
- mental confusion
- severe drop in BP
- cardiac irregularities
Do not try to treat the symptoms on your own, as they may be a sign of a more dangerous health problem. If a symptom is causing you concerns, seek professional medical advice as soon as possible.
Unsafe Drug Interactions
Sildenafil is recognized to have potentially dangerous interactions with certain other medications. To eliminate risks to your health, always inform your prescribing doctor about any prescription and over-the-counter medications, as well as dietary or herbal supplements that you are using. The following is a list of substances that should not be taken concurrently with sildenafil:
- nitrates for heart problems (nitroglycerin, isosorbide mononitrate, etc.)
- alkyl nitrites (recreational drugs or ‘poppers’)
- sGC stimulators for chronic thromboembolic pulmonary hypertension (riociguat)
- other ED meds that fall into the PDE5 inhibitor class (vardenafil, tadalafil, avanafil)
- HIV drugs (atazanavir, ritonavir, etc.)
- certain anti-fungal medications (itraconazole,ketoconazole)
- certain antibiotics (erythromycin)
- alpha-blockers (alfuzosin, terazosin)
- blood pressure-regulating medications (amlodipine)
If taken together with Sildenafil, these medicines may trigger a number of unpleasant or even life-threatening side effects, such as a severe drop in blood pressure, fainting, extreme dizziness, problems with one’s vision, priapism.
Note that this list is not complete, and there might be some other medications your doctor should know about before they can prescribe you with Sildenafil or any other ED drug.
Who should not take Sildenafil?
Sildenafil isn’t suitable for all individuals and must be entirely avoided or used with extreme care by those experiencing any of the subsequent conditions:
- allergies
- heart problems
- heart attack
- stroke
- hypertension or hypotension
- pulmonary venoocclusive disease
- Peyronie disease
- sickle cell anemia
- stomach ulcer
- hepatic or renal problems
Warnings
Avoid self-prescribing sildenafil or any other ED medication without first consulting your doctor. Only a qualified medical professional can confirm an erectile dysfunction diagnosis and provide a prescription for this medication.
Refrain from using Sildenafil for purposes not mentioned on the package insert unless explicitly instructed to do so by a licensed physician.
Steer clear of obtaining Sildenafil from unverified sources. Always take the time to check the legitimacy of a pharmacy if you opt to fill your sildenafil prescription online.